somatropin.review http://somatropin.review somatropin.review Thu, 05 Oct 2017 14:13:31 +0000 en-US hourly 1 https://wordpress.org/?v=4.4 Somatropin: all details you need http://somatropin.review/index.php/2016/02/19/somatropin-all-details-you-need/ Fri, 19 Feb 2016 10:07:37 +0000 http://somatropin.review/?p=34 Biosoma; Genotropin; Dzhintropin; Kreskormon; Norditropin (Norditropin NordiLet, PenSet Norditropin, Norditropin simplex); Rastan; Saizen; Growth Hormone; somatropin; Humatrop. Somatropin – preparations of pituitary human growth hormone. Growth hormone – somatropin – a powerful metabolic hormone influences on lipid metabolism, carbohydrate and protein. It has an anabolic effect and stimulates growth. As in adults, and children maintain […]

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Biosoma; Genotropin; Dzhintropin; Kreskormon; Norditropin (Norditropin NordiLet, PenSet Norditropin, Norditropin simplex); Rastan; Saizen; Growth Hormone; somatropin; Humatrop.

Somatropin – preparations of pituitary human growth hormone. Growth hormone – somatropin – a powerful metabolic hormone influences on lipid metabolism, carbohydrate and protein. It has an anabolic effect and stimulates growth. As in adults, and children maintain normal structure of the body, stimulating the growth of muscles, promotes the metabolism of body fat, increases strength, energy and subjective well-being. It is used for replacement therapy. Children: Growth hormone deficiency in the body (pituitary dwarfism, pituitary dwarfism); Turner’s syndrome; kidney failure in children in pre-adolescent, accompanied by growth retardation. In adults: a pronounced growth hormone deficiency with known hypothalamic-pituitary pathology; pronounced growth hormone deficiency with manifestation in childhood. It is also used in osteoporosis and immunodeficiency syndromes, accompanied by weight loss. Details

Active-active substance:

Somatropin / Somatropin.

Dosage Forms:

The lyophilisate (freeze-dried powder, the dry matter) for solution for injection (ampoules, vials, cartridges).

Complete solution for injection (in cartridges).

The pre-filled multidose disposable pen for repeated injections.

Somatropin (growth hormone)

Properties / Action:

Somatropin – preparations of pituitary human growth hormone. Growth hormone – somatropin – a powerful metabolic hormone influences on lipid metabolism, carbohydrates and proteins; It has anabolic and growth stimulating effect.

Growth hormone is a polypeptide containing 191 amino acid residues and has a molecular weight of about 22.125 kDa.

DNA recombinant somatropin for injection is a polypeptide hormone produced by recombinant DNA technology (e.g., synthesized strain of Escherichia coli, which has been modified by the addition of human growth hormone gene). The amino acid sequence of the recombinant growth hormone is identical to that of human growth hormone produced by the pituitary gland.

Effects of growth hormone induced directly by itself or indirectly via the synthesis and release of IGF-1 (IGF-1 / insulin-like growth factor / somatomedin-C). Somatropin treatment of children with growth hormone deficiency increases the concentration of their IGF-1 and IGF-binding protein-3 IRFSB.

Somatropin stimulates linear growth in children who do not have enough of normal endogenous growth hormone in children with short stature and gonadal dysgenesis associated with Turner’s syndrome or chronic renal insufficiency. Read more

As in adults, and children somatropin maintains a normal body composition, stimulating muscle growth and promoting fat metabolism. In adult patients with growth hormone deficiency growth hormone reduces fat mass, increases muscle mass and strength, energy, and subjective well-being.

It is shown that growth hormone and / or human growth hormone of pituitary origin have the following effects:

  1. exhibits anabolic effect (stimulates the transport of amino acids into cells and promotes protein synthesis), counteracts the catabolism;
  2. It stimulates the growth of the skeleton, bones;
  3. causes an increase in the number and size of muscle cells;
  4. increases body weight;
  5. It causes a delay in the body of nitrogen, mineral salts (calcium, phosphorus and sodium) and liquid;
  6. stimulates the absorption of calcium from the gastrointestinal tract;
  7. stimulates lipolysis, it causes a decrease in fat accumulation, reduces the flow of triglycerides in the fat depots (especially sensitive to somatropin visceral adipose tissue);
  8. It causes an increase in fatty acids in plasma concentration;
  9. increases blood sugar (initially reduces sensitivity to insulin, which can be retrieved later or even improved due to the beneficial effects of growth hormone on body cytoarchitectonics).
  • Effect of growth hormone on skeletal growth. Somatropin stimulates skeletal growth in patients with growth hormone deficiency. A notable increase in body length after administration of growth hormone due to their influence on the growth plates of long bones. The concentration of IGF-1, which may play a role in skeletal growth in serum of children with growth hormone deficiency is low, but it increases the treatment somatropin. In patients with growth hormone deficiency and osteoporosis somatropin prolonged treatment leads to recovery of the mineral composition and bone density. Somatropin activates the synthesis of chondroitin sulfate and collagen, increases the excretion of hydroxyproline. There has also been an increase in average concentration of serum alkaline phosphatase.
  • Effect of growth hormone on cell growth and physical performance. It has been shown that short children with deficient endogenous growth hormone less skeletal muscle cells than in healthy children. somatropin treatment leads to an increase in both the number and size of skeletal muscle cells, increases muscle strength and physical endurance. Somatropin also increases cardiac output, but the mechanism of this effect is not yet known. A role it can play in reducing the total peripheral vascular resistance (SVR). Furthermore, Somatropin causes an increase in the number and size of liver cells, thymus gland, gonads, adrenal gland and thyroid.
  • Effect of growth hormone on protein metabolism. Linear growth is partly accelerated by increasing the synthesis of cellular proteins. Initiation of treatment is somatropin nitrogen retention, which manifests itself in lowering its excretion in the urine and blood urea nitrogen in serum.
  • Effect of growth hormone on carbohydrate metabolism. Children with hypopituitarism are bouts of fasting hypoglycemia, which are in the treatment of somatropin. Somatropin increases insulin levels and can cause hyperglycemia, but the fasting blood glucose level is typically not altered.
  • Effect of growth hormone on lipid metabolism. In patients with growth hormone deficiency growth hormone administration leads to a mobilization of lipids, decrease body fat stores and increase in fatty acids in plasma concentration. Somatropin stimulates LDL receptors in the liver, and acts on lipid and lipoprotein profile in serum. The whole purpose of growth hormone in patients with growth hormone deficiency leads to a decrease in serum LDL and apolipoprotein B. You may also experience a decrease in total cholesterol levels.
  • Effect of growth hormone on mineral metabolism. Lack of growth hormone associated with a reduction in the blood plasma volume and tissue fluid. Both of these figures are rising rapidly after the start of somatropin therapy. Somatropin causes sodium retention, potassium and phosphorus. In patients with growth hormone deficiency after somatropin treatment increases the concentration of inorganic phosphate in the blood serum. The loss of calcium (acceleration of renal release) is offset by an increase in its absorption in the digestive tract; Serum calcium levels were not significantly changed.
  • Effect of growth hormone on the mental status. In patients with growth hormone deficiency may be violated mental ability and mental status. Somatropin increases vitality, improves memory and affect the balance of neurotransmitters in the brain.

Somatropin not possess toxic, mutagenic and carcinogenic effects.

Pharmacokinetics:

Approximately 80% of growth hormone is absorbed into the systemic circulation following subcutaneous injection. The absolute bioavailability appears the same for both male and female persons. Maximum plasma concentration is reached after 3.6 hours. After subcutaneous injection at 0.1 IU / kg, the maximum concentration is 13-35 ng / mL. It is metabolized in the liver. The half-life is 3-4 hours. Displayed through the intestines. Details

Indications:

Somatropin is used for replacement therapy in children and adults:

Somatropin is used in children:

growth hormone deficiency in the body (pituitary dwarfism, pituitary dwarfism); children with growth retardation due to growth hormone deficiency;

Prior to the use of somatropin diagnosis should be confirmed by functional assays pituitary gland condition. Stimulation of growth is only possible as long as there was no closure of growth zones.

Turner syndrome, confirmed by chromosome analysis;

A characteristic feature of Turner’s syndrome is low growth and gonadal dysgenesis. The reason for growth retardation in these patients is not known until the end. Growth hormone secretion is normal to about 9 years, then in most cases decreases.

kidney failure in children in pre-adolescent, accompanied by growth retardation;

For growth inhibition in these patients can result in the following factors: renal osteo-dystrophy, anemia, acidosis, malnutrition. However, it is believed to be the main cause disturbances in the system are: growth hormone / insulin-like growth factor-1 (IGF-1). Conservative treatment of renal insufficiency should not be interrupted in connection with the appointment of somatropin. During treatment with somatropin should be monitored renal function.

Somatropin is used in adults:

pronounced growth hormone deficiency with known hypothalamic-pituitary pathology proven by two provocative tests;

If you find during adulthood as a result of hypothalamic-pituitary insufficiency of growth hormone deficiency may be associated with a deficit of more of a hormone (except for prolactin), on which adequate replacement therapy prior to initiating therapy somatropin should be assigned.

pronounced growth hormone deficiency with manifestation in childhood;

Revealed in childhood growth hormone deficiency should be confirmed again before the start of somatropin replacement therapy.

osteoporosis;

Immunodeficiency syndromes accompanied by weight loss.

Dosage and administration:

Somatropin may be appointed only by doctors with special training in the treatment of growth hormone deficiency.

Preparations of recombinant somatropin are designed for subcutaneous or intramuscular administration. The dry substance is dissolved in the supplied solvent. The resulting solution should be clear and free of suspended particles. For each administration of growth hormone is necessary to use a sterile needle.

Some drugs are also used special somatropin injection device (injector Genotropin Pen 16 Genotropin; syringe pen NordiPen for Norditropin simplex; injector Humatro Pins II for the Humatropa etc.).

Applied dose of somatropin are individual and depend on weight, body surface area, patient’s response to treatment.

Preference is given daily by subcutaneous injection in the evening.

To prevent the development of lipoatrophy somatropin injection site should be varied.

Somatropin treatment should be started with the main recommended doses.

Basic recommended dose of growth hormone:

Growth hormone deficiency in children (dysplasia with insufficient secretion of growth hormone):

The recommended weekly dose of somatropin is 0.5-0.7 IU / kg body weight or 12-16 IU / m ^ 2 body surface area, which is spread on 6-7 s / c injection.

Somatropin subcutaneously administered at 0.07-0.1 IU / kg (0,025-0,035 mg / kg), 6-7 times a week, or 2.3 IU / m ^ 2 body surface (0.7-1.0 mg / m ^ 2) 6-7 times a week.

Somatropin intramuscularly appoint 0,14-0,2 U / kg 3 times a week, or 4.6 IU / m ^ 2 body surface 3 times per week.

It reported on the use and higher doses of somatropin.

Turner Syndrome:

Daily subcutaneous administration of higher dosages as compared with growth hormone deficiency in children: Somatropin administered subcutaneously at 0.14 IU / kg (0.045-0.050 mg / kg) 7 times a week (1.0 IU / kg per week) or 4.3 IU / m ^ 2 (1.4 mg / m ^ 2) 7 times a week (30 IU / m ^ 2 per week).

Chronic renal failure in children, accompanied by growth retardation:

Daily subcutaneous administration of higher dosages as compared with growth hormone deficiency in children: Somatropin administered subcutaneously at 0.14 IU / kg (0.045-0.050 mg / kg) 7 times a week (1.0 IU / kg per week) or 4.3 IU / m ^ 2 (1.4 mg / m ^ 2) 7 times a week (30 IU / m ^ 2 per week).

In case of insufficient growth rate may be needed higher doses. After 6 months of treatment may require dose adjustment somatropin.

Adults with growth hormone deficiency:

Somatropin dose is adjusted individually. It is recommended to begin treatment with low doses of 0,018 IU / kg (0.006 mg / kg or 0,45-0,9 IU / day) per day, gradually increasing the dose at monthly intervals, to a maximum of 0.036 U / kg (0.012 mg / kg) in a day. When selecting a dose somatropin take into account the clinical effect of adverse reactions and determining the level of IGF-1 in blood serum, which may serve koiteriaem adequacy dose. More elderly patients typically require a lower dose of Somatropin. Somatropin maintenance dose varies from patient to patient, but rarely exceeds 1.0 mg / day (equivalent to 3.0 IU / day).

The maximum dose of growth hormone replacement therapy is 0.1 mg / kg (0.3 IU / kg) and injected 3 times per week.

Overdose:

Acute overdose of somatropin may first lead to hypoglycemia, subsequently replaced by hyperglycemia.

Chronic overdose of somatropin can theoretically occur symptoms characteristic of endogenous growth hormone excess: gigantism and acromegaly.

In these cases, a removal of the drug.

Contraindications:

  • any signs of tumor growth, cancer (anti-tumor therapy should be completed prior to the start of somatropin therapy, intracranial tumor should be inactive, when the signs of regrowth of the tumor administration of somatropin should be discontinued);
  • idiosyncrasy (including a history of hypersensitivity) growth hormone;
  • closure of epiphyseal growth zones of long bones (not designated as a growth promoter for children);
  • patients in critical condition, urgently develop as a result of open heart surgery or abdominal cavity, multiple trauma and acute respiratory failure;
  • pregnancy and lactation (at the time of treatment should abandon breastfeeding);
  • kidney transplant (in children with chronic renal insufficiency treatment should be discontinued).

Application of pregnancy and breastfeeding:

Somatropin is contraindicated in pregnancy and lactation.

Although the description of the clinical cases of growth hormone during pregnancy and there is currently no proven safety of treatment with growth hormone during pregnancy. Thus, Somatropin is contraindicated during pregnancy, and therapy should be interrupted in case of pregnancy in a patient.

We should not forget about the possibility of release of growth hormone from the mother’s milk.

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Somatropin: reviews, advice and benefits http://somatropin.review/index.php/2016/02/14/somatropin-reviews-advice-and-benefits/ Sun, 14 Feb 2016 05:43:23 +0000 http://somatropin.review/?p=31 Growth Hormone is to this day one of the best drugs for prolonged muscle building. So far it is the only drug that causes athletes to forget about the bad genetic inheritance. Injections of growth hormone – it is always some risk because some phenomena are not reversible. But, despite the risk of potential side […]

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Growth Hormone is to this day one of the best drugs for prolonged muscle building. So far it is the only drug that causes athletes to forget about the bad genetic inheritance. Injections of growth hormone – it is always some risk because some phenomena are not reversible. But, despite the risk of potential side effects, it is still one of the most popular drugs in athletes. Growth hormone is surrounded by an aura of mystery in its application. Some call it a miracle means that in a short time gives a huge increase in strength and muscle mass.

Others consider it completely useless in achieving sports results and explain it by the fact that the drug stimulates the growth of only “dwarfs”: lagging behind in physical development of children. Some people think that growth hormones in adults cause a terrible bone deformities in the form of the Habsburg jaw and tremendous growth. There is also a complete mess: how to use growth hormones and in what dosage? Disagreements over hormones are so complex that the reader must have some initial basic information to understand the problem. Details

 

Growth Hormone – a polypeptide consisting of 191 amino acids. It is produced by the human pituitary gland and is released when the relevant stimuli (eg training, sleep, stress, low blood sugar). And here it is important to understand that the liberated human growth hormone does not have any direct influence itself on the body, but only stimulates the liver and subsequent release into the blood, and insulin-like growth factors, somatomedins. They have different effects on the body. The only problem is that the liver can develop a limited number of these substances, so that the effect of these substances on the body is limited. If hormone injections administered externally, they only stimulate the liver to produce and release these substances in the blood and does not have, as stated above, the direct impact.

 

Until the mid-80s there was only active in the human form as an exogenous source of introduction into the body. It is extracted from the pituitary of dead that had to be extremely costly. When, in 1985. receiving human growth hormone became associated with the extremely rare disease Krayufalda Jakob disease (disease of the brain), which faded for a dementia and death, some, but not all manufacturers began to remove the drug from the proizvodstva.K Fortunately, science is not dozing, and has created a synthetic hormone growth which produce genetically engineered muscle from transformed cells. And seychast it is sold in many countries.

 

The use of three ways growth hormone affects the athlete in his achievements. In – First, the strongest growth hormone has an anabolic effect that promotes intense fusion protein that is expressed in muscle hypertrophy (increase in muscle cell size) and muscle hyperplasia (increase in number). hyperplasia effect is extremely interesting, because steroids do not give it. Perhaps this is the reason that STH is called the strongest anabolic hormone. Second, growth hormone exerts a strong influence on the process of burning fat. He strongly converts fat into energy, leading to the intensity of his disappearance, and it allows the athlete to use a greater number of calories. Third, it often goes unnoticed, so that STH strengthens the connective tissue, tendons, bones and cartilage, and this is probably one of the main reasons for the incredible growth of the forces, which is seen in some athletes. Bodybuilders and powerlifters report that STH protects, thanks to this quality, the athletes from injury, if at the same time taking steroids strength is growing rapidly.

 

But with all this, there are many athletes who took growth hormone and have not made any serious progress either. There are several explanations.

 

  1. Athlete regularly received insufficient amounts of the hormone, and, moreover, even for a short time. This is due to the fact that growth hormone – a very expensive drug, and for many in the necessary dose is unaffordable.

 

  1. When applying samatotropina increases body’s need for thyroid hormone, insulin, corticosteroids, gonadotropins, estrogens, as well as in androgen hormones. This is the reason that STH, taken as a single drug is not very effective. Wink its phenomenal growth hormone anabolic properties could only by sharing a steroids, thyroid hormone, and insulin (see. Insulin). Only in this case the liver and may generate the optimum amount of releasing insulinodobnyh somatomedins and growth factors. This anabolic formula can be further strengthened while taking substances with anti-catabolic properties, steroids and Clenbuterol. Only then comes a synergistic effect.

 

Yet once again return to the anabolic formula: growth hormone, insulin and L-T3. Most athletes have taken growth hormone in the preparation phase for the competition, ie, in the diet phase with a reduced number of calories. In this phase, the body reduces insulin and thyroid hormone L-T3. What is described above in paragraph 2, it is not the good condition for growth hormone. Those who combine Clenbuterol with STH should know that Clenbuterol (like Ephedrine) also reduces the own production of insulin and L-T3. We recognize that everything written here is rather difficult to understand, but it is necessary to know in order to maximize the effect of the use of growth hormone. We need to understand that growth hormone affects many hormones of the human body, and it makes it impossible to receive a simple scheme. Read more

 

Before we get to the very difficult subject of dosages and dosing regimens, the question arises: who will generally take growth hormones? Athletes almost all the power and speed sports, as evidenced by the quote: “Charlie Francis, the Canadian coach athlete Ben Johnson described how Ben and numerous athletes of the Olympic Games burst with growth hormones forward Francis has convincing arguments in favor of using athletics stars in the US. growth hormones. in short, not for the press, talk with a professional athlete bodybuilding named Gary Straydem, this incredibly massive athlete made clear that he is absolutely certain that growth hormone use almost all professional bodybuilding. he also added that he had nothing afraid of the doping control until they are tested for growth hormone. ” Professional footballer Pile Altsaf, who died of a brain tumor (author’s note: There is a version that perhaps he died from illness Jacob Creutzfeld), shortly before his death, admitted that taking hormones for 16 weeks, and said that 80% of US professional footballers also take growth hormone. “Many of the best fighters use growth hormones while paying thousands of dollars a year.” Due to the fact that the top athletes are often accused of taking growth hormones, it only fuels the interest in them in the non-professional circles. (Daniel Duchaine, A Guide to the underground steroids).

 

On the question of the proper dosage and duration of admission is rather difficult to answer. Because not conducted research on the effects of growth hormone on athletes, so you can only come from experience. With the growth of pituitary insufficiency caused by the absence or insufficient release of growth hormone by the pituitary gland, manufacturers are advised to: a weekly dose on average 0,6me / kg body weight. Those. 100kg first athlete would have to receive weekly injections 60me. This dose would be divided into three intramuscular injections of 20me vtechenie week. Another method of administration: subcutaneous injection, which must be administered daily, most frequently by 8me day. Top athletes, who have enough money to take daily 4-8me. Because STH has a half-life of less than one hour, many athletes divide their daily dose into 2-3 small subcutaneous injections of 2me.

The introduction of regular small doses is considered to be more effective. On the grounds there. As we know, STH stimulates the liver to produce and release somatomedins and insulin-like factors, which cause the body’s desired effects.

Because the liver can only produce a limited amount of these two substances, one can question the fact that for large injections of the liver is able to produce just the appropriate amount of somatomedin and insulin-like growth factors. Therefore, the liver responds better to frequent and small dosage. Who introduces a solution of growth hormone in the same place, notice that at the injection site occurs disappearance of adipose tissue.

Because the injection site should constantly change in order to avoid local lipotrofii (disappearance of adipose tissue). In just a few years after all it turned out that the effect of growth hormone is highly dependent on the dosage. This means that: a stocked money and take it properly, or you just throw your money away.

 

Effectively this 4-8me active dose per day. For comparison: the hypophysis of a healthy adult daily highlights 0.5-1.5me growth hormones. Course duration depends mostly on the financial capacity of the athlete. Based on experience, taking STH most often at least 6 weeks to several months.

 

Interestingly, the effects of the hormone does not decrease after a few weeks, so at the same dosage achieved permanent gains. Bodybuilders have a positive experience with growth hormone, report that the accumulated power and, especially, for the most part preserved muscles and after receiving the hormone. American physician Dr. William N. Taylor, confirms this in his book “Anabolic steroids and athletes”, where one can read: “Statements of the athletes that made the strength and weight after taking hormone stored, means an increase in the number of muscle cells (hyperplasia) in. nature, strength and muscles can grow further months later, as extended to the newly acquired muscle cells stimulated through training of muscle hypertrophy. ”

 

Undesirable effects of growth hormones, the so-called side effects, this is a very interesting topic that is causing heated debate. First of all, it should be noted that growth hormone causes the side effects are not similar to those observed when taking anabolic / androgenic steroids such as: reducing its own testosterone production, acne, hair loss, aggressiveness, elevated estrogen level, the phenomenon of virilization in women reinforced water and salt retention, etc.

 

There are two main problems: the first is the possible lack of sugar in the blood, and the second, the possible hypothyroidism, so it can not be used for diabetes and thyroid disorders. In very rare cases there is an antibody response after a few months after the initiation of growth hormone. But what about the horror stories about acromegaly, bone deformation increase in heart problems with various organs, gigantism, and early death? To answer this, it is necessary to distinguish between hormones intake in the pre – and poslepubertanny periods. Growth is possible if a person is in dopubertannom period. After the possible gains or bones due to hypersecretion of endogenous growth hormone or due to excessive inflow of exogenous growth hormone. People suffering from an endogenous hypersecretion in poslepubertanny period and finished with normal growth can occur acromegaly, ie bone becomes thicker, wider, but not longer. Sometimes there is some growth in the hands and feet, as well as an increase in facial features due to overgrowth of the lower jaw and nose. Heart muscle and kidneys can increase in volume and weight, which sometimes can lead to diabetes and heart disease that could theoretically lead to death. In this and speculating media, they represent extreme cases with sick people as examples and for scaring vdalblivanie athletes about what fate awaits them when taking growth hormones.

And yet it is so unlikely as the reality showed that these examples should not be taken into account. Among the many athletes taking growth hormone is relatively small two-meter Neanderthals with extended jaw and 56 feet in size. To avoid misunderstandings, we do not want to mitigate the side effects that occur in healthy adults, but we want to try to explain that acromegaly, diabetes, myocardial hypertrophy, high blood pressure, kidney and liver growth can theoretically occur when excessive debt and taking growth hormone. But in practice they are very rare.

More frequent problems with STH occur, judging from experience, when the athlete intends to inject insulin in addition and does not do it correctly. The substance somatropin is a dry powder prior to injection and should be divorced enclosed solution in a vial. The final solution should be administered immediately, or be stored in a refrigerator, but no more than 24 hours. It is advised to store in the refrigerator and unused medication. The biological activity of growth hormones when stored at room temperature (15-25S) for up to 4 weeks is not reduced, and should still prefer a cool place (2-8S).

 

{Mospagebreak “Oh, this is really a great product – the best way to build muscle is the only drug that makes you forget even about the bad genetic predisposition, as it helps to achieve a gain in muscle mass ANY HGH -.. Is the greatest risk, to which an athlete can go, because the side effects are irreversible and, in spite of it all, we love this drug. “, – he said about growth hormone in his book” Handbook of underground steroid “famous steroid guru Daniel Ducheyn.

 

Growth hormone – the most mysterious and controversial drug of those included in the arsenal of competing bodybuilders. Some believe that without it is impossible to make the championship form, others believe that he simply does not work, affecting only dwarfs, others told terrible things about the side effects caused by taking this medicine: grown to immense sizes jaws, noses and superciliary arches. And what is HGH really?

 

For a start – a little chemistry.

 

Growth Hormone – a polypeptide hormone consisting of 191 amino acids. It is produced by the human pituitary gland and is released when the relevant stimuli (eg, exercise, stress, sleep, irritation, low blood sugar). It is important to understand that produced as a result of this growth hormone does not have a direct impact on the body, but only stimulates the release of insulin into the blood growth factors and somatomedins, which some accepted and for the cause. The problem is that the liver is capable of producing only a limited number of these substances. And if hormones are injected from the outside, they only encourage the liver to produce and release these substances on the body without causing direct impact. Details

 

Until the mid-80s, there was only a natural human growth hormone, which was extracted from the pituitary of dead people. You understand that this procedure was incredibly expensive. When in 1985, receiving human growth hormone became associated with the extremely rare disease Krayufelda Jakob disease (disease of the brain), which entailed dementia and death, manufacturers began to remove the drug from the production. Today, almost do not sell human growth hormone injection (exception – Lithuanian “Growth Hormone”). Fortunately, science is not dozing, and invented a synthetic growth hormone, which is produced by genetic engineering and transformed muscle cells. Nowadays the artificial growth hormone sold in many countries under different trade names: “Humatrop”, “Norditropin”, “Somatosorm”, “Somatogen” etc.

 

How does the growth hormone?

 

In essence, it acts on the body in three ways. Firstly, it has a strong anabolic effect and enhances protein synthesis, resulting in muscle hypertrophy (increase in muscle cell size) and hyperplasia of muscle – to increase their number. The latter property growth hormone is unique in that anabolic steroids do not give a similar effect. Perhaps this is the reason that STH is called the strongest anabolic hormone. Secondly, the growth hormone exerts a strong influence on the burning of fat. He is intensely burns fat, it allows the athlete to consume more calories. Third, what is often overlooked, STH strengthens the connective tissue, tendons, bones and cartilage, which, apparently, is one of the main reasons for the incredible growth of the forces, which is seen in some athletes. Some bodybuilders and lifters are convinced that in this way the growth hormone protects them from injury, the likelihood of which increases dramatically the growth of parallel operating weights accompanying steroids. In addition, an increase in bone, cartilage, tendons and internal organs makes the athlete REALLY MASSIVE. And it is – not the mass, which “leaves”, as it happens when the user “gets off” on steroids.

 

However, some athletes tried growth hormone, we have not felt any positive changes. Why did this happen?

 

  1. Dosage was too low and / or it is used long enough. These concerns are understandable, since growth hormone is very expensive.

 

  1. Growth hormone used alone. The fact is that when taking the growth hormone rises sharply in the body’s need for thyroid hormone, insulin, corticosteroids, gonadotropins, estrogen, and steroids. Therefore, if the growth hormone is adopted alone, the effect is significantly reduced its effects. In fact, in order that the body was in an optimal anabolic state required three hormones: growth hormone, thyroid hormone A3 (Cytomel) and insulin. Only in this case, the liver is able to produce enough insulin somatomedins and growth factors. This anabolic state can be further enhanced by taking drugs that have pronounced anti-catabolic properties, such as clenbuterol. However, those who are going to combine the receiving growth hormone with clenbuterol or ephedrine, need to know that these drugs reduce the level of production of insulin hormone, and L3. A similar reduction occurs when the athlete sits on a rigid diet precontest.

 

  1. Instead of the growth hormone you slipped a fake or low-quality drug. Few people know how to actually should look like this drug, which is used by the dealers “black market”. At the pharmacy you it is unlikely to get it. At least, without a prescription. As for the poor quality of the preparation, it is known that growth hormone must be stored in a cool place, otherwise it starts to decompose. Therefore, if it is written on the bottle that it contains 4000 international units of growth hormone, there is no guarantee that they will not 3000 or 2000.

 

How to take growth hormone? In what dosage? How long?

 

These questions are difficult to answer, because there are no laboratory tests to this effect have been conducted. You can only rely on the experience of familiar with this piece of athletes. With the growth of pituitary insufficiency caused by the absence or low emission growth hormone by the pituitary gland, the manufacturers advise taking the drug weekly rate of 60 IU per 1 kg of body weight. Thus, an athlete weighing about 100 kg, must inject themselves about 6000 IU of HGH. At this dose of 6000 IU desirably divided into three doses of 2,000 IU. Another option – subcutaneous injection, which would have cost to enter each day, approximately 8,000 IU per day. The average dosage of top athletes is around 4000-8000 IU growth hormone daily. Because the half-life of growth hormone – less than an hour, many athletes prefer a daily dose divided into two parts, which are administered in the morning on an empty stomach and at night before bedtime – it is not considered optimal. Furthermore, since the liver is unable to produce insulin-like growth factors and somatodieny in limited quantities, it simply can not absorb large dosage of growth hormone from the outside, which again favors fractional receiving this drug.

 

Although some bodybuilders swear that they have achieved stunning results, taking all day and 2000 IU of growth hormone, you, if you are serious about working with this drug, it is necessary to stock up a decent amount of money to count still at 4,000 IU per day. Growth hormone should be taken either in a large amount, or not taken at all, because it simply does not work in a small dose, as described above.

 

As for the duration of the course, it should be at least six weeks and may last for several months. It is believed that the risk of side effects increases, if the duration of admission passes for six months. Interestingly, the effects of the hormone does not decrease after a few weeks after starting, so to increase the dosage, as is customary in the case of steroids, it makes no sense.

 

Positive properties of growth hormone consists in the fact that achieved with the help of strength and muscle volume, as a rule, do not decrease after the course. This is because, as already mentioned, with an increase in the number of muscle cells. Due to this, many athletes unable to progress for many months after the end of receiving growth hormone.

 

Another interesting feature of growth hormone is that frequent injections it in the same location may result in burn-in at this point fat. So it makes sense to introduce the drug in different body sites.

 

I would like to talk a bit about how growth hormone interacts with insulin. In fact, not too advanced athletes is not recommended to supplement the intake of growth hormone externally administered insulin – enough to fully eat every 3 hours. Thus you will maintain insulin levels are high enough. In addition, keep in mind that too much insulin makes you fat, because excess insulin activates certain enzymes which convert glucose into glycerol, and then in the triglycerol. On the other hand, too low a level of insulin in the blood, which is most likely to occur during the period of “drying” before the competition, dramatically reduces the effects of growth hormone on the body. The ideal option would be to find a doctor who would do you tests on blood and urine sugar levels and determine how much insulin you need.

 

Side effects.

 

Arising when receiving growth hormone side effects have nothing to do with adverse effects, which give steroids. I mean reduction of body testosterone, aggression, verilizatsiyu women, acne, water retention, increased estrogen levels, etc. The main problem – it is usually possible lack of sugar in the blood (the risk of diabetes) or possible hypothyroidism. Rarely occurring antibodies to growth hormone is not essential. As for the enhanced growth of individual organs and limbs, they, if they occur, in the pre-adolescent (that is, when a person has not yet formed) or poslepubertatnom, but only in people who suffer hypogonadal (hypogonadism). People suffering from an endogenous hypersecretion, acromegaly can occur poslepubertatny period. Bones become thicker, wider, but not longer. There is increased growth of hands and feet, as well as an increase in facial features due to overgrowth of the lower jaw and nose. Heart muscle and kidneys can increase in volume and weight. Often this ends with the onset of general weakness, diabetes, heart disease and premature death.

 

The media understandably inflate isolated cases to the level of universal tragedy, but it is recognized that the podium is not clogged with two-meter athletes with jaws like a Neanderthal. The above diseases are extremely rare, and in the case of very long-term use of growth hormone in very large doses. But such luxury can afford not everyone, given that the Lithuanian growth hormone production, the most widespread in the Russian market, worth approximately 5.5-8 dollars per vial containing 4000 IU of dry matter. The preparation is a light powder enclosed in a glass vial, to which was attached a vial with a solution (usually a solution of novocaine). The final solution should be administered immediately or stored in the refrigerator, but no more than 24 hours. It should be stored in the refrigerator and unused medication. Although the biological activity of growth hormone begins to decline only after four weeks of storage at room temperature, it is better to store it in the refrigerator.

 

Growth hormone is included in the number of doping, but almost “caught” on doping control, which makes it very popular among competing at the international level athletes. However, it may soon be supplanted by growth hormone open American and Australian scientists insulin-like growth factor, which allows the body to receive external getting more of the substance required to produce their own somatodienov and insulin-like growth factor. So the “chemical” bodybuilders is to pray for science, the possibility of which, it seems limitless!

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Somatropin: results, side effects and courses http://somatropin.review/index.php/2016/02/09/somatropin-results-side-effects-and-courses/ Tue, 09 Feb 2016 08:58:34 +0000 http://somatropin.review/?p=28 Somatropin – drug growth hormone. This pharmacological drug is released from the network of pharmacies by prescription only. Somatropin: reviews and description Instructions to somatropin suggests that the hormonal drug stimulates the process of skeletal and somatic growth, while providing a pronounced effect on the metabolic processes occurring. This hormonal drug can effectively make up […]

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Somatropin – drug growth hormone. This pharmacological drug is released from the network of pharmacies by prescription only.

Somatropin: reviews and description

Instructions to somatropin suggests that the hormonal drug stimulates the process of skeletal and somatic growth, while providing a pronounced effect on the metabolic processes occurring. This hormonal drug can effectively make up for lack of endogenous growth hormone, promotes the normalization of the structural body composition by increasing sheathe muscle mass and reducing fat tissue. Most of somatropin rendered effects realized through the insulin-like growth factors of the first type, produced by all cells. Details

The product is characterized by the ability to cause Somatropin gain adjustment processes of bone tissue, which manifests itself in a persistent increase in the indicators of bone markers. Adults who take this remedy, in the first months of treatment had greater resorption process of bone structure anastrozole 1mg side effects, was observed to decrease its weight, but in the case of continuation of a course of therapy of bone mass increases with firmness.

INDICATIONS Reception somatropin

The use of somatropin shown with symptoms of growth retardation in children because of the existing deficiency (deficiency phenomena), growth hormones, with growth retardation in girls when available gonadal sex glands, the syndrome of Turner, with growth retardation in prepubertal due to a chronic form of kidney failure .

Adult use of pharmacological agents Somatropin is shown as a means of substitution therapy with clinically proven form of acquired and congenital deficiency of growth hormone. The product Somatropin is also used in growth hormone deficiency, as well as pathologies of the hypothalamic-pituitary system.

CONTRAINDICATIONS somatropin

The use of growth hormone is contraindicated in case of hypersensitivity, symptoms actively flowing malignancy syndrome, Prader-Willi, when urgent conditions, during lactation, and with proliferative diabetic preproliferative form of retinopathy during pregnancy.

Somatropin use caution with concomitant intracranial hypertension, diabetes mellitus, hypothyroidism.

SIDE EFFECTS somatropin

Application Somatropin agents can cause intracranial hypertension, transient paresthesias, joint pain, fluid retention in the body, cutaneous rash, muscle pain, the development of peripheral edema, production of antibodies to somatropin, allergic reactions, itching sensation, redness, soreness, numbness, swelling injection area. Read more

PRECAUTIONS FOR SEEING somatropin

Somatropin treatment should always carry out a medical professional with special expertise for growth hormone deficiency and treatment of this type of pathology.

Reviews of somatropin suggest that the simultaneous application of corticosteroids can suppress the growth process and to reduce the influence exerted by this drug.

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Hormone to increase human growth – somatropin http://somatropin.review/index.php/2016/02/03/hormone-to-increase-human-growth-somatropin/ Wed, 03 Feb 2016 22:46:06 +0000 http://somatropin.review/?p=26 Hormone to increase human growth – growth hormone (somatropin). Human growth can change during a person’s lifetime. The most rapid growth usually ends in 16-18 years. The further increase its growth is also possible, but not as much as up to this age. One option – the increase in the body of the two hormones. […]

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Hormone to increase human growth – growth hormone (somatropin). Human growth can change during a person’s lifetime. The most rapid growth usually ends in 16-18 years. The further increase its growth is also possible, but not as much as up to this age. One option – the increase in the body of the two hormones. This so-called Gamon growth: growth hormone (somatropin), and somatomedin.

 

Hormone to increase human growth – growth hormone (somatropin) growth hormone HGH is released by the pituitary gland, that it stimulates the body’s production of somatomedin acting on cells through which is an increase in human growth. Somatomedin produced in the liver. Every day of the human body is released less than 5% of the somatotropin contained in the pituitary. And, in fact, some of this growth hormone is destroyed without being liberated. Details

 

The activity of the hormone somatotropin depends on how well the human body is provided with zinc. Experts estimate a person does not receive the required amount of zinc. This means that to increase the growth of the human to be applied multivitamins containing zinc.

 

Contact food and growth hormone (somatropin), which affects the increase in growth.

 

If we talk about food, the increase in the allocation of growth hormone in the human body, and consequently growth occurs at the use of low-fat protein. For example, cottage cheese or lean meat. But the fat and sweet food on the contrary reduce and inhibit release of growth hormone, and as a result – slow growth.

 

Contact vitamins and growth hormone (somatropin), which affects the increase in growth.

 

With the combination of vitamins C and E increases the somatotropin content in the blood of 20-25%. To do this, use the 150 milligrams of vitamin C daily, and 100 milligrams of vitamin E once in two days. An increase in growth hormone (growth hormone) in the blood by 20-25% is not enough. So if there was a direct proportionality between the growth of the person and the level of growth hormone, the person 170 cm in height, would increase its growth up to 209 cm. It’s a pity that this is not always the case, and such a powerful effect does not happen, but, despite this, increase in growth clearly takes place.

 

In one of the experiments have shown that nicotinic acid increases the level of growth hormone in the blood of 2 times or more, due to the inhibition of fat mobilization.

 

Communication exercise and growth hormone (somatropin), which affects the increase in growth.

Increasing human growth occurs also from swimming and jogging. So it makes sense at least once a week, use of the pool and do jogging. In addition, there is evidence that an increase in the growth occurs from visiting bath, by a short-term increase in growth hormone, so visiting it 1-3 times a week, you will be able to further increase its growth.

 

Communication sleep and growth hormone (somatropin), which affects the increase in growth.

 

It is important to increase growth – a dream, because during sleep is produced by the largest number of growth hormone, and if you’re a little sleep and sleep do not comply, then greatly reduces the chances to grow. To make it more clear, 70% of the daily amount of growth hormone is released just in time for sleep, so this is probably the most important thing you should pay attention.Read more

 

The greatest amount of growth hormone released during the beginning of a deep sleep, which is why the dream should be full. Another stimulant to increase growth and growth hormone is a chiseled physical and psychological stress. A great stress is pouring cold water in the morning and evening.

 

Contact of food with high content of protein and growth hormone (somatropin), which affects the increase in growth.

 

In his diet should include more protein food because it stimulates the production of the hormone in the blood. The most valuable protein for growing – is certain amino acids, such as ornithine, L-arginine, tryptophan, leucine and leucine. Some of these amino acids can be purchased in a pharmacy or in a store of sports nutrition. The most effective dose of each of these amino acids is 0.5 grams per kilogram of your body. Details

 

Thus, increasing the daily dose of this hormone, you increase your height.

 

Besides all this, it is desirable to perform a special set of exercises designed specifically to increase growth.

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What is Somatropin and how does it work? http://somatropin.review/index.php/2016/01/21/what-is-somatropin-and-how-does-it-work/ Thu, 21 Jan 2016 03:56:27 +0000 http://somatropin.review/?p=14 Growth hormone – growth hormone (Somatotropin), produced by the pituitary gland and soon dies, but only half an hour of his life, it produces in the body a lot of changes and effects, both direct and indirect. The direct effect of growth hormone – a consequence of the fact that growth hormone is closely binds […]

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Growth hormone – growth hormone (Somatotropin), produced by the pituitary gland and soon dies, but only half an hour of his life, it produces in the body a lot of changes and effects, both direct and indirect.

The direct effect of growth hormone – a consequence of the fact that growth hormone is closely binds its receptor on target cells. Muscle cells, like fat, have growth hormone receptors. Therefore, growth hormone (Somatotropin), joining the fat cells begins to encourage them to break down triglyceride and suppresses their ability to uptake circulating lipids.

What happens in your body in the generation of the somatotropin?

While as somatotropin (Somatotropin) reaches the liver, and the process starts stimulating IGF-1. Simultaneously with this process begins production hormone chondrocytes (cartilage cells), resulting in the growth and strengthening of bones. Details

IGF-1 is also partially affects both production and myoblast differentiation (stem cells for skeletal muscle fibers). Furthermore, IGF-1 stimulates amino acid uptake and protein synthesis in muscle and other tissues.

Also, growth hormone (Somatotropin) stimulates protein anabolism. This leads to an increase in protein synthesis, the reduction and oxidation of proteins, increased absorption of amino acids. As mentioned earlier, Growth hormone accelerates fat utilization by stimulating triglyceride breakdown of fats and oxidation of fat cells.

GENERAL effect on human body and thyroid.

 

Importantly, Growth Hormone (Somatotropin) may affect the function of other hormones. For example, he successfully inhibits the function of insulin to stimulate glucose uptake in tissues and no less successfully fights with increasing glucose synthesis in the liver. Thus, Somatotropin successfully maintains the level of insulin in the liver. Read more

It can be concluded: Growth hormone stimulates the production of insulin. If the abuse that growth hormone and not adhere to the application circuit, which may result in higher concentrations of insulin (hyperinsulinemia). And as a consequence of a reduction of insulin sensitivity and hyperglycemia.

Growth Hormone (Somatotropin) significantly inhibited the production of thyroid hormones. Effect of Growth Hormone (Somatotropin’a) thyroid varies and is specific to each person.

Of the benefits of OR THAT IT WILL GIVE ME?

 

The wide range of growth hormones, which will help you to maintain and restore the health of almost all the major systems of the body. Fell as a child? We get strong tension? Fracture? Growth Hormone phenomenally quickly builds new cartilage, bone, muscle cells.

In addition, it helps the body absorb protein, reduces the oxidation of protein and accelerates the process of burning fat cells. That’s why many athletes and fans so admired this drug. More info

Dear visitors: You can place your order via the feedback form on the home page, as well as any convenient manner specified in the “Contacts” section.

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Somatropin – whether is it able to improve athletic performance and to prolong your youth? http://somatropin.review/index.php/2016/01/21/somatropin-whether-is-it-able-to-improve-athletic-performance-and-to-prolong-your-youth/ Thu, 21 Jan 2016 03:55:56 +0000 http://somatropin.review/?p=12 Write a brief overview of the international investigations, a clinical use of growth hormone induced passion for me the regular course of injections somatotrpina one of my friends – almost a professional bodibidldera. Among body builders somatotorpin touted as a means of prolonging youth, means to combat fat deposits, and means to build muscle and […]

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Write a brief overview of the international investigations, a clinical use of growth hormone induced passion for me the regular course of injections somatotrpina one of my friends – almost a professional bodibidldera. Among body builders somatotorpin touted as a means of prolonging youth, means to combat fat deposits, and means to build muscle and improve muscle relief. It is believed that the constant rate of growth hormone in moderation is safe. Details

 

Let’s see whether the use of growth hormone yields positive results improving the quality of life, improve athletic performance and whether the use of growth hormone does not entail nikakh ospasnostey?

 

The excitement associated with the use of growth hormone effects chudodestvennymi began with the publication in 1990 of Dr. Rudman D et Nathaniel under the Effects of human growth hormone on men over 60 years old [New England Journal of Medicine 323: 1-6, 1990].

 

In this study Dr. Rudman participated in a total of 12 healthy men aged 61 to 81 years with the level of insulin-like growth factor I (somatomedin C – is an important endocrine intermediary action of growth hormone and its concentration reflects the content of growth hormone in the organism) to syvortke blood lower than healthy young people. The subjects received growth hormone – growth hormone for 6 months at a dose twice the standard terpaevticheskuyu dose for the treatment of growth hormone deficiency. The starting dose was 0.03 mg somatotropin per kilogram of body weight. Injections of growth hormone were carried out subcutaneously three times a week. In the future, when it detects the subjects insufficient level of insulin-like growth factor-I hormone dose was increased by 25%, and in excess of the level – reduced by 25%. Read more

 

Subjects followed a diet with a daily intake of 25-30 kcal per kg body weight (2500 – 3000 kcal per 100 kg body weight). The subjects were followed for 12 months (6 months in nazanachenii somatotropin +6 months after receiving the growth hormone).

 

What results have been achieved as a result of the injection of growth hormone:

 

All subjects had no change in the blood picture, blood biochemistry, urinalysis, ECG.

 

Subjects receiving somatrotpin, after the 12-month observation period had a significantly higher blood pressure and blood sugar levels compared with the period destination somatotropin.

 

Subjects received no somatotropin showed an increase in muscle mass by an average 4.7 kg and a reduction in fat mass by 3.5 kg. Also, lint bone density increased by 0.02 grams per square centimeter.

 

The authors did not make any statement about the rejuvenating effects of growth hormone, and honestly noted that many of the questions that they could not get ki answers. However, the article was cited argument that the effect of muscle mass and reduce fat tissue from the use of growth hormone has been equivalent to the “rejuvenation of 10-20 years.”

 

Although described in the study, side effects such as hypertension and the potential diabetogenic capacity growth hormone, inspired by the phrase about “rejuvenation effect for 10-20 years,” growth hormone manufacturers have started advertising their products strengthened as a miracle cure for the return of youth. As of the 2004-2005 year in the US from 20 to 30 thousand people have used growth hormone as a “means of rejuvenation,” “slimming during sleep”, and means to build muscle by spending up to $ 1,000 per month for his preparty at that the free sale of growth hormone in the United States prohibited all growth hormone drugs purchased illegally over the Internet. Also suschestvet intact class of dietary supplements that stimulate the production of growth hormone. Athletes should be aware that the growth hormone (hGH – human growth hormone) is prohibited for use doping WADA (World Anti-Doping Agency).

 

In 2003, New England Journal of Medicine even had to publish a clarification to the article Rudman, 1990, to prevent speculation and misinterpretation of published materials, “published results of the study can not serve as the basis for clinical guidelines.” [Drazen JM. Inappropriate advertising of dietary supplements. New England Journal of Medicine 348: 777-778, 2003.]

An example of Internet advertising “excellent somatotrpina” Forget about aging and diet forever! ”

The customer promise of growth hormone:

  • Reduction of adipose tissue – up to 82%
  • Reducing the number of wrinkles – up to 61%
  • Increase energy levels – up to 84%
  • Increase skusualnoy potency – up to 75%
  • Memory Improvement – 62%
  • Improving muscle strength up to 88%

And note – in advertising link to the aforementioned article in the New England Journal of Medicine!

Let’s see how these promotional data correspond to the real situation, confirmed by clinical trials of growth hormone as the elderly and young people. Details

 

Endocrinologist of Stanford University Hau Liu, impressed by the scale of uncontrolled use of growth hormone, analyzed 31 statistically significant clinical study of the effects of growth hormone use in healthy older people, most of whom suffered slight obesity. These clinical studies have covered a total of 500 subjects, with an average follow-up was 6 months. The aim of this research was to investigate the clinical effect of Applications sosmatotropina in healthy older people.

 

What were the results of these studies on the use of growth hormone:

 

  • The amount of growth hormone significantly uvelivaet muscle Tacna, an average of 2 kg and 2 kg reduces the amount of fat tissue in the body.

 

  • The use of growth hormone does not change the important functional indicators of physiological state of the body, such as maximum oxygen consumption. Also, the use of growth hormone does not increase bone density Tacna, does not reduce the content of lipoproteins in the blood.

 

  • The use of growth hormone can have a number of side effects.

 

Thus, Hau Liu concluded that there was no significant clinical evidence that growth hormone is capable of “anti-aging” and to produce “anti-aging effect.”

 

The American Association of Clinical Endocrinologists has warned that the clinical use of growth hormone – growth hormone as an anti-aging treatment, or for patients with ordinary obesity is not recommended [AACE guidelines support proper use of growth hormone replacement therapy. American Association of Clinical Endocrinologists news release, Sept 9, 1999].

 

Separately Hau Liu conducted a similar study, the purpose of which was to determine the effects of growth hormone on athletic performance and physical fitness in healthy young people. [Hau Liu The Effects of Growth Hormone on Athletic Performance / Annals of Internal Medicine May 20, 2008 vol. 148 no. 10 747-758]

 

It has been studied 27 clinical trials of growth hormone at 303 young people (average age 27 years), athletic build in good physical shape. On average, subjects were administered growth hormone at a dose of 36 ?g / kg per day for 20 days.

 

The survey of the result was found:

 

  • The use of growth hormone has led to an increase in muscle mass by an average of 2.1 kg (1.3 to 2.9 kg)
  • The use of growth hormone did not increase muscle strength and endurance.
  • The use of growth hormone resulted in an increase sodrezhaniya lactate during exercise.
  • The use of growth hormone resulted in moderate swelling of the soft tissue due to water retention and muscle weakness.

 

Thus, the study showed that the use of growth hormone does not improve the performance of fitness test. Somatorpin causes muscle growth. but it does not lead to uuvelicheniyu muscle strength. Somatropin is able to degrade the endurance and cause side effects. Details

 

However, a study commissioned by the World Anti-Doping Agency WADA in 2011 in Australia [U. Meinhardt The Effects of Growth Hormone on Body Composition and Physical Performance in Recreational Athletes Annals of Internal Medicine, May 4, 2010 vol. 152 no. 9, 568-577] has shown that the use of growth hormone can improve performance in races on the bike for a short distance from the non-professional athletes.

Somatropin was administered for eight weeks.

The use of growth hormone did not improve performance in the jump, did not improve aerobic capacity, did not increase muscle strength and performance in heavy lifting.

Thus, the above data show that the only clinically proven dostvernym application somatotrpina result may be an increase in muscle mass of 2 kg and a decrease in fat mass on the same 2 kg per 3-8 weeks of growth hormone.

Compare these results with the claimed “miraculous” effects of advertising somatotrpina …

What is possible to pay in addition to considerable sums of money for the small effect obtained free of charge at the gym?

In contrast to the effect of growth hormone, which increases a muscle mass, improve training and functional condition of the body. [Taaffe DR and others. Effect of recombinant human growth hormone on the muscle strength response to resistance exercise in elderly men. Journal of Clinical Endocrinology and Metabolism 79: 1361-1366, 1994]. Intensive training with a substantial increase physical activity levels of endogenous growth hormone and 10 (!) Times. Horsham deep long sleep also contributes to the development of endogenous growth hormone. (Remember the myth of the children that we grow in a dream?). It stimulates the production of growth hormone and stress hyperthermia. Lowers growth hormone overeating and hyperglycemia. [Ehrnborg C., Bengtsson BA., Rosen T., Growth hormone abuse. Best Pract Res Clin Endocrinol Metab, 2000, 14 (1), 71-77. ]

 

Comparison of the effect of training without the use of growth hormone and growth hormone intake in the elderly have shown no significant difference statitsticheski. This study has once again confirmed that it is much healthier and cheaper to do in the gym, you assign yourself an injection of growth hormone. Besides the use of growth hormone in the elderly may increase the risk of prostate cancer in men. [M.L. Vance Retrospective: Can Growth Hormone Prevent Aging? N Engl J Med 2003; 348: 779-780]

 

There is evidence that taking growth hormone can stimulate the generation of connective tissue between the muscle fibers. This effect may contribute to a better resistance to high loads or damage at least kortoky period. The sides of the other growth hormone such effect results in the loss of muscle strength. Also receiving somatotropin reduces the accuracy of the exercises requiring koordintsatsii movements, and slow recovery time after exercise. [M Rennie Claims for the anabolic effects of growth hormone: a case of the Emperor’s new clothes? Br J Sports Med. 2003 April; 37 (2): 100-105. ]

 

Long-term use of growth hormone increases the risk of type 2 diabetes, causes fluid retention in the body, can cause joint and muscle pain, cause hypertension, cause myocardial hypertrophy and kidney, resulting in cardiomyopathy, osteoporosis, dysmenorrhea in women, impotence in men and cause an increase in lipoprotein (cholesterol) in the blood. [Humbel RE, Insulin-like growth factors I and II. Eur J Biochem, 1990, 190 (3), 445-462. ] Read more

 

Conclusions:

 

  1. There is currently no clinically proven results of the effectiveness of growth hormone as a means of “rejuvenation.”

 

  1. Clinically confirmed the ability of growth hormone to increase muscle mass and reduce fat mass in the body Tacna at the rate of 3-8 weeks, to a limited extent (by an average of 2 kg). Clinically confirmed somatoropina ability to improve performance at short-term physical activity (velosprint).

 

  1. The use of growth hormone does not improve functional capabilities of the organism (the maximum consumption ksiloroda, muscular strength, endurance). Conventional regular sports training is given not only a change in the structural composition of the body, but also increase the functionality of the body.

 

  1. The risk of complications sposbnyh significantly impair quality of life in long-term continuous use of growth hormone significantly higher than the value of “sulpturnyh” effects of the use of growth hormone.

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Somatropin: effects, dosage and buying http://somatropin.review/index.php/2016/01/21/somatropin-effects-dosage-and-buying/ Thu, 21 Jan 2016 03:54:56 +0000 http://somatropin.review/?p=10 Somatropin, or growth hormone (“catfish” in Latin means “body”) – bioregulator is a polypeptide produced by the anterior pituitary gland. This material was used in sports (preferably bodybuilding) for generating the perfect relief of muscle.   Biosynthetic growth hormone Somatropin includes preparations of protein nature, possessing species-specific. This bio-active product obtained by genetic engineering, is […]

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Somatropin, or growth hormone (“catfish” in Latin means “body”) – bioregulator is a polypeptide produced by the anterior pituitary gland. This material was used in sports (preferably bodybuilding) for generating the perfect relief of muscle.

 

Biosynthetic growth hormone Somatropin includes preparations of protein nature, possessing species-specific. This bio-active product obtained by genetic engineering, is discharged as a dry lyophilized powder for injection, which is attached to the vial with the solvent. With anabolic properties of growth hormone stimulates the process of hematopoiesis and enhances protein synthesis. Unlike other modern anabolic steroids that are used in sport, action somatropin directed at increasing the number of muscle cells. As a result, after the abolition of the hormonal drug strength, muscle mass and volume, not only do not decrease, but still continue to progress for many months. Details

 

Pharmacological properties

 

  • has anabolic effects (increases muscle growth);
  • protects muscle from breakdown (anti-catabolic is – blocker cortisol);
  • It regulates energy expenditure, promotes accelerated healing of wounds, enhances immune strength of the body;
  • reduces body fat, strengthens bone tissue;
  • young age stimulates the synthesis of growth factors, creates optimal levels of nutrients;
  • It prevents the absorption of glucose by tissues, increasing its concentration in the blood;
  • It stimulates the re-growth of atrophied with age internal organs.

The use of growth hormone in bodybuilding

 

Currently, human growth hormone (its recombinant form) find their wide application in medical and in sports practice. This drug not only increases protein mass, but also promotes the development of carbohydrate-saving mechanism, switching to fat channels. Read more

 

Anabolic means made on the basis of growth hormone do not have androgenic activity, do not adversely affect the potency, do not violate the normal functioning of the arc “hypothalamus-pituitary-testes”, do not require post-cycle therapy.

 

Those who wish to increase the mass and become the owner of the ideal muscle relief, the company offers to buy Peptits.ru Somatropin. On our Internet portal presents only original manufactured amino acid-based drugs, issued in the form of powders for injection.

 

Price Somatropin is readily available, and the quality of products sold satisfies all the charges to her requirements and standards, as confirmed by the relevant certificates. Details

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Growth hormone – Somatropin: results and buying http://somatropin.review/index.php/2016/01/21/growth-hormone-somatropin-results-and-buying/ Thu, 21 Jan 2016 03:54:07 +0000 http://somatropin.review/?p=8 In our store you can buy growth hormone delivery across Ukraine. There is a large variety of products on the basis of growth hormone: haygetropin, dzhintropin and so on. The growth hormone, you can buy in an ordinary pharmacy, but the cost will be much higher. We can offer a decent price, advisory support, a […]

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In our store you can buy growth hormone delivery across Ukraine. There is a large variety of products on the basis of growth hormone: haygetropin, dzhintropin and so on. The growth hormone, you can buy in an ordinary pharmacy, but the cost will be much higher. We can offer a decent price, advisory support, a large selection of products and speed of delivery. Details

 

Growth hormone is one of the most powerful anabolic hormones: it promotes the growth of muscle, strengthens bones, is involved in the burning of body fat (most strongly in the waist area). Somatropin has a lasting effect. This means that the result achieved during the cycle, immediately after taking the drug will not be lost. It persists for a long time. Growth hormone is able to simultaneously solve several problems facing the athlete: Helps to get rid of body fat, strengthens joints and ligaments, helps build lean muscle mass. The positive effects can be safely attributed the restoration of atrophied or damaged internal organs, disease prevention and overall strengthening of immunity. Some effects have unique properties, nor in any other active drugs are not shown, for example, the restoration of cartilage tissue.

 

The mechanism of the growth hormone somatropin:

  • Shift metabolism to use fat as an energy source.
  • Total renewal of cartilage (in order hyperplasia), synovial fluid, runningaway collagen.
  • Strengthening in the process of bone deposition of calcium ions (because of complex hormonal transformations).
  • Hyperplasia (the formation of new muscle filaments, fibrils and an increase in the synthesis of its own proteins, as well as an increase in the number of fibers, cell nuclei).
  • Activation of satellite cells of muscle fibers (miosatellitotsitov), ??their rapid division to hit the nuclei in muscle fibers.

 

Exogenous growth hormones is completely harmless. Somatropin is produced by the body, so is his natural substance. All adverse effects are the result of prolonged (more recommended), use of the substance in excessive dosages. Thus, if you want to buy growth hormone in our shop and get acceptance for its detailed free consultation, please contact listed on the site. Read more

 

If you need to buy peptides hubbub growth or other drugs, just read the catalogs of our online store, where you will surely find one product that are looking for. All products that are sold in our store is different with affordable prices and high quality!

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Growth Hormone – Somatropin: the pharmacological action http://somatropin.review/index.php/2016/01/21/growth-hormone-somatropin-the-pharmacological-action/ Thu, 21 Jan 2016 03:53:39 +0000 http://somatropin.review/?p=6 Growth hormone (somatropin, growth hormone, growth hormone HGH) – a drug growth hormone identical to human growth hormone. It is obtained by synthesis using recombinant technology. Other commercial name somatotropin: Kigtropin, Neotropin, Dynatrop, Ansomon, Jintropin etc.. Somatotropin body fills amount of endogenous human growth hormone. Read more It is a powerful stimulator: It promotes the […]

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Growth hormone (somatropin, growth hormone, growth hormone HGH) – a drug growth hormone identical to human growth hormone. It is obtained by synthesis using recombinant technology.

Other commercial name somatotropin: Kigtropin, Neotropin, Dynatrop, Ansomon, Jintropin etc..

Somatotropin body fills amount of endogenous human growth hormone. Read more

It is a powerful stimulator:

It promotes the growth and differentiation of osteoblasts and chondrocyte epifiznogo.

The increase in cell growth of cartilage, the cushioning material.

The expansion of the pineal gland.

Other actions of growth hormone:

  • It accelerates the body’s reactions during the synthesis of protein.
  • Regulate the content of Rh-negative nitrogen arising after surgery or injury.
  • Corrects hypoproteinemia that occurs in cirrhosis or infection.
  • It stimulates the synthesis of macrophage, lymphocyte immune globulin and the growth of lymphoid formations.
  • It increases the body’s resistance to infection.
  • It stimulates the growth of fibroblasts, kollagenotsita macrophages at sites affected burn or after surgery, promotes rapid healing of wounds.
  • It accelerates the synthesis cardiocytes.
  • It improves the contractile function of the heart muscle, helps reduce its dependence on medical oxygen saturation.
  • It regulates the process of fat metabolism.
  • Suppresses serum cholesterol levels.
  • It reduces a density protein.
  • Regulates and normalizes the amount of growth hormone.
  • Improves osteometabolizma, kidney function and the heart (in adults).

Implementation of most of the effects of growth hormone and actions carried out by the IGF-I (IGF-I). Developing it runs every cell of the body, its largest supplier in the body are the liver cells. IGF-I to 90% or more is connected with proteins (IRFSB) weighty role among them is assigned IRFSB protein-3.

Growth hormone enhances all the processes occurring in the restructuring of the bone tissue, increasing the activity of biochemical markers of bone present in the plasma. Details

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The use of Somatropin in bodybuilding and fitness http://somatropin.review/index.php/2016/01/21/the-use-of-somatropin-in-bodybuilding-and-fitness/ Thu, 21 Jan 2016 03:52:55 +0000 http://somatropin.review/?p=4 Growth hormone (somatotropin, growth hormone) – a hormone released by the anterior pituitary. In sports, GH got immense popularity because of its ability to provide a pronounced increase in muscle mass, to form relief while burning body fat. Recombinant growth hormone in bodybuilding is often combined with anabolic steroids to achieve the most pronounced anabolic […]

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Growth hormone (somatotropin, growth hormone) – a hormone released by the anterior pituitary. In sports, GH got immense popularity because of its ability to provide a pronounced increase in muscle mass, to form relief while burning body fat. Recombinant growth hormone in bodybuilding is often combined with anabolic steroids to achieve the most pronounced anabolic effect. Details

Synonyms: growth hormone, growth hormone, growth hormone, growth hormone, HGH.

The positive effects of growth hormone action:

– Launches a powerful anabolic processes in the body;

– It has anti-catabolic effects, preventing the destruction of muscle mass;

– Marked reduction of body fat;

– The effect of general rejuvenation;

– Strengthens the immune system and accelerates the regeneration of tissues; It has wound-healing effect;

– Ureplyaet bones, and causes them to increase in people with no-go zones of bone growth about 26 years).

Growth hormone – one of the most effective drugs used by people with age-related changes. With age, the secretion of your own (endogenous) growth hormone has been steadily declining in the elderly it is minimal: reduced basic level of growth hormone, as well as the frequency and peaks aplituda secretion. Therefore, regularly receives an exogenous growth hormone helps stimulate the re-growth of atrophied internal organs, activates cell growth and regeneration of bone and soft tissue.

The use of GR in bodybuilding

Growth hormone is an absolute favorite among professional athletes – due to good growth of lean muscle mass, reduce body fat, as well as its ability to strengthen the connective tissue (cartilage, tendon) and bone structure. Due to the latter property GR reduces the incidence of injuries, as well as faster the healing of injured areas of the body and restoring them. Moreover, it is perhaps the only way to induce hyperplasia of muscle fibers in vorzrastnyh athletes who achieve this without the use of growth hormone is almost impossible. Read more

Use of growth hormone will provide the relief of the musculature, without the risk of side effects: GH has no effect on the potency, has no androgenic activity after use there is no need to carry out aftertreatment therapy as somatotropin not interfere with the function of the arc hypothalamus-pituitary-testes. As shown, the monthly rate of growth hormone gives the unspoken (2-4 kg), but very high quality growth of lean muscle mass; In some cases, the total weight may not change due to the loss of body fat.

Note that Somatropin is a fundamentally different mechanism of action compared to anabolic steroids. Undoubtedly, the most significant, visible and qualitative results of the athlete reaches using growth hormone in conjunction with steroids with high androgenic activity (methane, testosterone, trenbolone).

Additional Facts:

  • The secretion of growth hormone occurs interval, with several peaks during the day (peak GH occurs every 3-5 hours). The highest peak of growth hormone secretion occurs during the night, about 1 hour after falling asleep.
  • The baseline concentration of GH in plasma is 1-5 ng / ml, but during peak concentration may rise to 10-45 ng / ml.

BUY growth hormone. PRICE GROWTH HORMONE.

In our online shop buy growth hormone is beneficial and safe. We only supply authentic products from manufacturers. You can obtain a full consultation from a specialist in our forum (address can be found in the horizontal menu). Details

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