Write a brief overview of the international investigations, a clinical use of growth hormone induced passion for me the regular course of injections somatotrpina one of my friends – almost a professional bodibidldera. Among body builders somatotorpin touted as a means of prolonging youth, means to combat fat deposits, and means to build muscle and improve muscle relief. It is believed that the constant rate of growth hormone in moderation is safe. Details
Let’s see whether the use of growth hormone yields positive results improving the quality of life, improve athletic performance and whether the use of growth hormone does not entail nikakh ospasnostey?
The excitement associated with the use of growth hormone effects chudodestvennymi began with the publication in 1990 of Dr. Rudman D et Nathaniel under the Effects of human growth hormone on men over 60 years old [New England Journal of Medicine 323: 1-6, 1990].
In this study Dr. Rudman participated in a total of 12 healthy men aged 61 to 81 years with the level of insulin-like growth factor I (somatomedin C – is an important endocrine intermediary action of growth hormone and its concentration reflects the content of growth hormone in the organism) to syvortke blood lower than healthy young people. The subjects received growth hormone – growth hormone for 6 months at a dose twice the standard terpaevticheskuyu dose for the treatment of growth hormone deficiency. The starting dose was 0.03 mg somatotropin per kilogram of body weight. Injections of growth hormone were carried out subcutaneously three times a week. In the future, when it detects the subjects insufficient level of insulin-like growth factor-I hormone dose was increased by 25%, and in excess of the level – reduced by 25%. Read more
Subjects followed a diet with a daily intake of 25-30 kcal per kg body weight (2500 – 3000 kcal per 100 kg body weight). The subjects were followed for 12 months (6 months in nazanachenii somatotropin +6 months after receiving the growth hormone).
What results have been achieved as a result of the injection of growth hormone:
All subjects had no change in the blood picture, blood biochemistry, urinalysis, ECG.
Subjects receiving somatrotpin, after the 12-month observation period had a significantly higher blood pressure and blood sugar levels compared with the period destination somatotropin.
Subjects received no somatotropin showed an increase in muscle mass by an average 4.7 kg and a reduction in fat mass by 3.5 kg. Also, lint bone density increased by 0.02 grams per square centimeter.
The authors did not make any statement about the rejuvenating effects of growth hormone, and honestly noted that many of the questions that they could not get ki answers. However, the article was cited argument that the effect of muscle mass and reduce fat tissue from the use of growth hormone has been equivalent to the “rejuvenation of 10-20 years.”
Although described in the study, side effects such as hypertension and the potential diabetogenic capacity growth hormone, inspired by the phrase about “rejuvenation effect for 10-20 years,” growth hormone manufacturers have started advertising their products strengthened as a miracle cure for the return of youth. As of the 2004-2005 year in the US from 20 to 30 thousand people have used growth hormone as a “means of rejuvenation,” “slimming during sleep”, and means to build muscle by spending up to $ 1,000 per month for his preparty at that the free sale of growth hormone in the United States prohibited all growth hormone drugs purchased illegally over the Internet. Also suschestvet intact class of dietary supplements that stimulate the production of growth hormone. Athletes should be aware that the growth hormone (hGH – human growth hormone) is prohibited for use doping WADA (World Anti-Doping Agency).
In 2003, New England Journal of Medicine even had to publish a clarification to the article Rudman, 1990, to prevent speculation and misinterpretation of published materials, “published results of the study can not serve as the basis for clinical guidelines.” [Drazen JM. Inappropriate advertising of dietary supplements. New England Journal of Medicine 348: 777-778, 2003.]
An example of Internet advertising “excellent somatotrpina” Forget about aging and diet forever! ”
The customer promise of growth hormone:
- Reduction of adipose tissue – up to 82%
- Reducing the number of wrinkles – up to 61%
- Increase energy levels – up to 84%
- Increase skusualnoy potency – up to 75%
- Memory Improvement – 62%
- Improving muscle strength up to 88%
And note – in advertising link to the aforementioned article in the New England Journal of Medicine!
Let’s see how these promotional data correspond to the real situation, confirmed by clinical trials of growth hormone as the elderly and young people. Details
Endocrinologist of Stanford University Hau Liu, impressed by the scale of uncontrolled use of growth hormone, analyzed 31 statistically significant clinical study of the effects of growth hormone use in healthy older people, most of whom suffered slight obesity. These clinical studies have covered a total of 500 subjects, with an average follow-up was 6 months. The aim of this research was to investigate the clinical effect of Applications sosmatotropina in healthy older people.
What were the results of these studies on the use of growth hormone:
- The amount of growth hormone significantly uvelivaet muscle Tacna, an average of 2 kg and 2 kg reduces the amount of fat tissue in the body.
- The use of growth hormone does not change the important functional indicators of physiological state of the body, such as maximum oxygen consumption. Also, the use of growth hormone does not increase bone density Tacna, does not reduce the content of lipoproteins in the blood.
- The use of growth hormone can have a number of side effects.
Thus, Hau Liu concluded that there was no significant clinical evidence that growth hormone is capable of “anti-aging” and to produce “anti-aging effect.”
The American Association of Clinical Endocrinologists has warned that the clinical use of growth hormone – growth hormone as an anti-aging treatment, or for patients with ordinary obesity is not recommended [AACE guidelines support proper use of growth hormone replacement therapy. American Association of Clinical Endocrinologists news release, Sept 9, 1999].
Separately Hau Liu conducted a similar study, the purpose of which was to determine the effects of growth hormone on athletic performance and physical fitness in healthy young people. [Hau Liu The Effects of Growth Hormone on Athletic Performance / Annals of Internal Medicine May 20, 2008 vol. 148 no. 10 747-758]
It has been studied 27 clinical trials of growth hormone at 303 young people (average age 27 years), athletic build in good physical shape. On average, subjects were administered growth hormone at a dose of 36 ?g / kg per day for 20 days.
The survey of the result was found:
- The use of growth hormone has led to an increase in muscle mass by an average of 2.1 kg (1.3 to 2.9 kg)
- The use of growth hormone did not increase muscle strength and endurance.
- The use of growth hormone resulted in an increase sodrezhaniya lactate during exercise.
- The use of growth hormone resulted in moderate swelling of the soft tissue due to water retention and muscle weakness.
Thus, the study showed that the use of growth hormone does not improve the performance of fitness test. Somatorpin causes muscle growth. but it does not lead to uuvelicheniyu muscle strength. Somatropin is able to degrade the endurance and cause side effects. Details
However, a study commissioned by the World Anti-Doping Agency WADA in 2011 in Australia [U. Meinhardt The Effects of Growth Hormone on Body Composition and Physical Performance in Recreational Athletes Annals of Internal Medicine, May 4, 2010 vol. 152 no. 9, 568-577] has shown that the use of growth hormone can improve performance in races on the bike for a short distance from the non-professional athletes.
Somatropin was administered for eight weeks.
The use of growth hormone did not improve performance in the jump, did not improve aerobic capacity, did not increase muscle strength and performance in heavy lifting.
Thus, the above data show that the only clinically proven dostvernym application somatotrpina result may be an increase in muscle mass of 2 kg and a decrease in fat mass on the same 2 kg per 3-8 weeks of growth hormone.
Compare these results with the claimed “miraculous” effects of advertising somatotrpina …
What is possible to pay in addition to considerable sums of money for the small effect obtained free of charge at the gym?
In contrast to the effect of growth hormone, which increases a muscle mass, improve training and functional condition of the body. [Taaffe DR and others. Effect of recombinant human growth hormone on the muscle strength response to resistance exercise in elderly men. Journal of Clinical Endocrinology and Metabolism 79: 1361-1366, 1994]. Intensive training with a substantial increase physical activity levels of endogenous growth hormone and 10 (!) Times. Horsham deep long sleep also contributes to the development of endogenous growth hormone. (Remember the myth of the children that we grow in a dream?). It stimulates the production of growth hormone and stress hyperthermia. Lowers growth hormone overeating and hyperglycemia. [Ehrnborg C., Bengtsson BA., Rosen T., Growth hormone abuse. Best Pract Res Clin Endocrinol Metab, 2000, 14 (1), 71-77. ]
Comparison of the effect of training without the use of growth hormone and growth hormone intake in the elderly have shown no significant difference statitsticheski. This study has once again confirmed that it is much healthier and cheaper to do in the gym, you assign yourself an injection of growth hormone. Besides the use of growth hormone in the elderly may increase the risk of prostate cancer in men. [M.L. Vance Retrospective: Can Growth Hormone Prevent Aging? N Engl J Med 2003; 348: 779-780]
There is evidence that taking growth hormone can stimulate the generation of connective tissue between the muscle fibers. This effect may contribute to a better resistance to high loads or damage at least kortoky period. The sides of the other growth hormone such effect results in the loss of muscle strength. Also receiving somatotropin reduces the accuracy of the exercises requiring koordintsatsii movements, and slow recovery time after exercise. [M Rennie Claims for the anabolic effects of growth hormone: a case of the Emperor’s new clothes? Br J Sports Med. 2003 April; 37 (2): 100-105. ]
Long-term use of growth hormone increases the risk of type 2 diabetes, causes fluid retention in the body, can cause joint and muscle pain, cause hypertension, cause myocardial hypertrophy and kidney, resulting in cardiomyopathy, osteoporosis, dysmenorrhea in women, impotence in men and cause an increase in lipoprotein (cholesterol) in the blood. [Humbel RE, Insulin-like growth factors I and II. Eur J Biochem, 1990, 190 (3), 445-462. ] Read more
- There is currently no clinically proven results of the effectiveness of growth hormone as a means of “rejuvenation.”
- Clinically confirmed the ability of growth hormone to increase muscle mass and reduce fat mass in the body Tacna at the rate of 3-8 weeks, to a limited extent (by an average of 2 kg). Clinically confirmed somatoropina ability to improve performance at short-term physical activity (velosprint).
- The use of growth hormone does not improve functional capabilities of the organism (the maximum consumption ksiloroda, muscular strength, endurance). Conventional regular sports training is given not only a change in the structural composition of the body, but also increase the functionality of the body.
- The risk of complications sposbnyh significantly impair quality of life in long-term continuous use of growth hormone significantly higher than the value of “sulpturnyh” effects of the use of growth hormone.